Upregulation of DNA repair genes in active cirrhosis associated with hepatocellular carcinoma | Zendy

Zindy Pierre | Zendy; Andrieux Lise | Zendy; Bonnier Dominique | Zendy; Musso Orlando | Zendy; Langouët Sophie | Zendy; Campion Jean Pierre | Zendy; Turlin Bruno | Zendy; Clément Bruno | Zendy; Théret Nathalie | Zendy

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Upregulation of DNA repair genes in active cirrhosis associated with hepatocellular carcinoma

Author(s) -

Zindy Pierre,

Andrieux Lise,

Bonnier Dominique,

Musso Orlando,

Langouët Sophie,

Campion Jean Pierre,

Turlin Bruno,

Clément Bruno,

Théret Nathalie

Publication year - 2005

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2004.09.092

Subject(s) - cirrhosis , downregulation and upregulation , gene , dna repair , hepatocellular carcinoma , fibrosis , biology , dna damage , gene expression , cancer research , dna , genetics , medicine , pathology

Phenotypic changes in injured livers involve complex network of genes whose interplays may lead to fibrosis and cirrhosis, a major risk of hepatocellular carcinoma. Gene expression profiles in fibrotic livers were analyzed by using cDNA microarray, hierarchical clustering and gene ontology. Analyses of a major cluster of upregulated genes in cirrhosis identified a new set of genes involved in DNA repair and damage. The upregulation of DNA repair genes was confirmed by real‐time quantitative polymerase chain reaction and associated with necroinflammatory activity ( P < 0.001). Increased DNA repair activity in cirrhosis with inflammatory activity may reflect increased DNA damages as a consequence of chronic liver injury.

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