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Upregulation of DNA repair genes in active cirrhosis associated with hepatocellular carcinoma
Author(s) -
Zindy Pierre,
Andrieux Lise,
Bonnier Dominique,
Musso Orlando,
Langouët Sophie,
Campion Jean Pierre,
Turlin Bruno,
Clément Bruno,
Théret Nathalie
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.09.092
Subject(s) - cirrhosis , downregulation and upregulation , gene , dna repair , hepatocellular carcinoma , fibrosis , biology , dna damage , gene expression , cancer research , dna , genetics , medicine , pathology
Phenotypic changes in injured livers involve complex network of genes whose interplays may lead to fibrosis and cirrhosis, a major risk of hepatocellular carcinoma. Gene expression profiles in fibrotic livers were analyzed by using cDNA microarray, hierarchical clustering and gene ontology. Analyses of a major cluster of upregulated genes in cirrhosis identified a new set of genes involved in DNA repair and damage. The upregulation of DNA repair genes was confirmed by real‐time quantitative polymerase chain reaction and associated with necroinflammatory activity ( P < 0.001). Increased DNA repair activity in cirrhosis with inflammatory activity may reflect increased DNA damages as a consequence of chronic liver injury.