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Molecular signature associated with plasticity of bone marrow cell under persistent liver damage by self‐organizing‐map‐based gene expression
Author(s) -
Omori Kaoru,
Terai Shuji,
Ishikawa Tsuyoshi,
Aoyama Kouji,
Sakaida Isao,
Nishina Hiroshi,
Shinoda Koh,
Uchimura Shunji,
Hamamoto Yoshihiko,
Okita Kiwamu
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.09.090
Subject(s) - gene , gene expression , transplantation , carbon tetrachloride , bone marrow , biology , plasticity , liver transplantation , gene signature , microbiology and biotechnology , cancer research , immunology , medicine , chemistry , genetics , materials science , organic chemistry , composite material
The mechanism that regulates the plasticity of bone marrow cells (BMCs) into hepatocytes is poorly understood. We developed a green fluorescent protein/carbon tetrachloride model to find that BMC transplantation recovered liver damage. Serum albumin level and liver fibrosis were recovered by BMC transplantation. To understand the mechanism, we used DNA‐chip technology to profile the change of transient gene expression before and after BMC transplantation. On the basis of gene expression with self‐organizing map using specific equation, genes were classified into 153 clusters. The information is useful to understand the dramatic gene activation during the process of the plasticity of BMC.