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Genistein induces Gadd45 gene and G 2 /M cell cycle arrest in the DU145 human prostate cancer cell line
Author(s) -
Oki Teruki,
Sowa Yoshihiro,
Hirose Tohru,
Takagaki Nobumasa,
Horinaka Mano,
Nakanishi Ryoko,
Yasuda Chikako,
Yoshida Tatsushi,
Kanazawa Motohiro,
Satomi Yoshiko,
Nishino Hoyoku,
Miki Tsuneharu,
Sakai Toshiyuki
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.09.085
Subject(s) - du145 , genistein , gadd45 , cancer research , prostate cancer , biology , cell culture , transcription factor , microbiology and biotechnology , gene , cancer , cell cycle checkpoint , cell cycle , chemistry , genetics , lncap
Genistein is the most abundant isoflavone of soybeans and has been shown to cause growth arrest in various human cancer cell lines. However, the precise mechanism for this is still unclear. We report here that the growth arrest and DNA damage‐inducible gene 45 (gadd45) gene is induced by genistein via its promoter in a DU145 human prostate cancer cell line. The binding of transcription factor nuclear factor‐Y to the CCAAT site of the gadd45 promoter appears to be important for this activation by genistein.