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An angiotensin II AT 1 receptor antagonist, telmisartan augments glucose uptake and GLUT4 protein expression in 3T3‐L1 adipocytes
Author(s) -
Fujimoto Muneya,
Masuzaki Hiroaki,
Tanaka Tomohiro,
Yasue Shintaro,
Tomita Tsutomu,
Okazawa Kayoko,
Fujikura Junji,
Chusho Hideki,
Ebihara Ken,
Hayashi Tatsuya,
Hosoda Kiminori,
Nakao Kazuwa
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.09.027
Subject(s) - telmisartan , glut4 , chemistry , endocrinology , medicine , angiotensin ii receptor antagonist , antagonist , glucose transporter , 3t3 l1 , receptor , angiotensin ii , angiotensin receptor , adipocyte , biochemistry , biology , adipose tissue , insulin , blood pressure
Evidence has accumulated that some of the angiotensin II AT 1 receptor antagonists have insulin‐sensitizing property. We thus examined the effect of telmisartan on insulin action using 3T3‐L1 adipocytes. With standard differentiation inducers, a higher dose of telmisartan effectively facilitated differentiation of 3T3‐L1 preadipocytes. Treatment of both differentiating adipocytes and fully differentiated adipocytes with telmisartan caused a dose‐dependent increase in mRNA levels for PPARγ target genes such as aP2 and adiponectin. By contrast, telmisartan attenuated 11β‐hydroxysteroid dehydrogenase type 1 mRNA level in differentiated adipocytes. Of note, we demonstrated for the first time that telmisartan augmented GLUT4 protein expression and 2‐deoxy glucose uptake both in basal and insulin‐stimulated state of adipocytes, which may contribute, at least partly, to its insulin‐sensitizing ability.