Premium
Involvement of IL‐1 family proteins in p38 linked cellular senescence of mouse embryonic fibroblasts
Author(s) -
Uekawa Natsuko,
Nishikimi Akihiko,
Isobe Ken-ichi,
Iwakura Yoichiro,
Maruyama Mitsuo
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.08.033
Subject(s) - embryonic stem cell , senescence , microbiology and biotechnology , biology , chemistry , genetics , gene
Senescence of mammalian cultured cells is essentially organized by a machinery of cell division and cellular stresses induced by various extracellular stimuli. Here, we show that in mouse embryonic fibroblasts (MEFs) culture in vitro, expression of an inflammatory cytokine, interleukin‐1β (IL‐1β) and its antagonist, IL‐1 receptor antagonist (IL‐1Ra) are induced by senescence. The kinetics of IL‐1β‐expression was similar to that of p38 activation during MEFs culture. We also found a distinguishable accelerated senescence in cell growth in IL‐1Ra deficient MEFs culture. Our results suggest that IL‐1β signaling pathway is involved in activation of p38 linked cellular senescence.