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Cyanidin‐3‐glucoside regulates phosphorylation of endothelial nitric oxide synthase
Author(s) -
Xu Jin-Wen,
Ikeda Katsumi,
Yamori Yukio
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.08.027
Subject(s) - enos , nitric oxide , cyclic guanosine monophosphate , phosphorylation , chemistry , endothelial nitric oxide synthase , nitric oxide synthase , nitric oxide synthase type iii , guanosine , soluble guanylyl cyclase , biochemistry , microbiology and biotechnology , guanylate cyclase , medicine , biology , organic chemistry
Dietary anthocyanins are widely distributed in fruits, vegetables and red wines, and there are several reports mentioning their beneficial effects. Previously we reported that cyanidin‐3‐glucoside (Cy3G) induced endothelial nitric oxide synthase (eNOS) expression and nitric oxide (NO) production in bovine vascular endothelial cells. In the present study, we show that Cy3G regulates phosphorylation of eNOS and Akt, affects the interaction between eNOS and soluble guanylyl cyclase, and increases cyclic guanosine monophosphate (cGMP) production. Our results suggest that Cy3G enhances vascular eNOS activity, and may help to improve vascular endothelial function.