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Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer
Author(s) -
Sgarra Riccardo,
Rustighi Alessandra,
Tessari Michela A.,
Di Bernardo Julie,
Altamura Sandro,
Fusco Alfredo,
Manfioletti Guidalberto,
Giancotti Vincenzo
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.08.013
Subject(s) - chromatin , cancer , chemistry , cancer research , microbiology and biotechnology , biology , biochemistry , genetics , dna
The structural characteristics of the three nuclear phosphoproteins of the high mobility group A family are outlined and related to their participation in chromatin structure alteration in many biological processes such as gene expression, neoplastic transformation, differentiation, and apoptosis. The elevated expression of these proteins in tumor cells and their post‐translational modifications, such as phosphorylation, acetylation and methylation, are discussed and suggested as suitable targets for cancer chemotherapy.