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Daily injection of insulin attenuated impairment of liver circadian clock oscillation in the streptozotocin‐treated diabetic mouse
Author(s) -
Kuriyama Koji,
Sasahara Kei,
Kudo Takashi,
Shibata Shigenobu
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.07.036
Subject(s) - streptozotocin , endocrinology , medicine , suprachiasmatic nucleus , circadian rhythm , clock , diabetes mellitus , insulin , rhythm , circadian clock , biology
Recent studies have shown a dampened amplitude of clock gene rhythm in the heart and liver of streptozotocin (STZ)‐treated rats and mice, however it is unknown whether impairment is due to dysfunction of the suprachiasmatic nucleus (SCN) or not. Rhythmic expression of mPER2 was dampened in the STZ‐treated mouse liver but not SCN and cerebral cortex. Injection of insulin could normalize an impairment of mPer2 and mPER2 expression rhythm in the liver, when it was injected at nighttime, but not at daytime. In the present study, we demonstrated that insulin‐dependent diabetes impaired oscillation of the peripheral clock gene and its product. Insulin injection can recover dampened oscillation of the peripheral clock depending on its injection time.