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Control of superoxide production in mitochondria from maize mesocotyls
Author(s) -
Camacho Adriana,
Moreno-Sanchez Rafael,
Bernal-Lugo Irma
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.06.024
Subject(s) - superoxide , mitochondrion , production (economics) , zea mays , chemistry , biology , agronomy , microbiology and biotechnology , biochemistry , enzyme , economics , macroeconomics
To understand the biochemical events that control the generation of superoxide, the effect of inhibiting the respiratory complexes III and IV (C‐III and C‐IV) and alternative oxidase (AOX) on the rate of superoxide production was analyzed in mitochondria from maize seedlings. To increase superoxide production, it was required to inhibit C‐III or C‐IV by at least 30% or 50%, respectively. Below this inhibition threshold, AOX exerted the highest degree of control on superoxide production, whereas above it, the highest degree of control was exerted by C‐IV. The contribution of C‐III to control superoxide production became significant when AOX activity was modulated.