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Histone deacetylase inhibitors regulate p21 WAF1 gene expression at the post‐transcriptional level in HepG2 cells
Author(s) -
Hirsch Calley L,
Bonham Keith
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.06.018
Subject(s) - histone deacetylase , hdac11 , histone deacetylase 5 , histone , histone deacetylase 2 , cyclin dependent kinase , histone deacetylase inhibitor , transcriptional regulation , biology , cancer research , regulation of gene expression , gene expression , microbiology and biotechnology , transcription (linguistics) , cell cycle , cyclin d1 , gene , genetics , linguistics , philosophy
Histone deacetylase inhibitors (HDIs) are thought to act primarily at the level of transcription inducing cell cycle arrest, differentiation and/or apoptosis in many cancer cell types. Induction of the potent cdk/cyclin inhibitor p21 WAF1 is a key feature of this HDI mediated transcriptional re‐programming phenomenon. However, in the current study we report that HDIs are also capable of inducing p21 WAF1 through purely post‐transcriptional events, namely increased mRNA stability. These studies highlight our growing appreciation for the complexities of HDI mediated effects and challenge our preconceptions regarding the action of these promising anti‐neoplastics.