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Possible involvement of AMP‐activated protein kinase in obesity resistance induced by respiratory uncoupling in white fat
Author(s) -
Matejkova Olga,
Mustard Kirsty J,
Sponarova Jana,
Flachs Pavel,
Rossmeisl Martin,
Miksik Ivan,
Thomason-Hughes Michaela,
Grahame Hardie D,
Kopecky Jan
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.06.002
Subject(s) - ampk , anabolism , protein kinase a , downregulation and upregulation , white adipose tissue , endocrinology , amp activated protein kinase , medicine , adipose tissue , adipocyte , chemistry , uncoupling agents , catabolism , adipogenesis , microbiology and biotechnology , kinase , biology , mitochondrion , biochemistry , metabolism , gene
The AMP‐activated protein kinase (AMPK) cascade is a sensor of cellular energy charge that promotes catabolic and inhibits anabolic pathways. However, the role of AMPK in adipocytes is poorly understood. We show that transgenic expression of mitochondrial uncoupling protein 1 in white fat, which induces obesity resistance in mice, is associated with depression of cellular energy charge, activation of AMPK, downregulation of adipogenic genes, and increase in lipid oxidation. Activation of AMPK may explain the complex metabolic changes in adipose tissue of these animals and our results support a role for adipocyte AMPK in the regulation of storage of body fat.