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Distinct regulatory mechanism of yeast GPX2 encoding phospholipid hydroperoxide glutathione peroxidase by oxidative stress and a calcineurin/Crz1‐mediated Ca 2+ signaling pathway
Author(s) -
Tsuzi Daisuke,
Maeta Kazuhiro,
Takatsume Yoshifumi,
Izawa Shingo,
Inoue Yoshiharu
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.05.077
Subject(s) - biochemistry , biology , oxidative stress , chemistry , phospholipid hydroperoxide glutathione peroxidase , glutathione , glutathione peroxidase , superoxide dismutase , microbiology and biotechnology , enzyme
The GPX2 gene encodes a homologue of mammalian phospholipid hydroperoxide glutathione peroxidase in Saccharomyces cerevisiae . Previously, we have reported that the oxidative stress‐induced expression of GPX2 is strictly regulated by Yap1 and Skn7 transcription factors. Here, we found that the expression of GPX2 is induced by CaCl 2 in a calcineurin (CN)/Crz1‐dependent manner, and the CN‐dependent response element was specified in the GPX2 promoter. Neither Yap1 nor Skn7 was required for Ca 2+ ‐dependent induction of GPX2 , therefore, distinct regulation for the oxidative stress response and Ca 2+ signal response for GPX2 exists in yeast cells.