Premium
Differential regulation of the insulin‐like growth factor II mRNA‐binding protein genes by architectural transcription factor HMGA2
Author(s) -
Brants Jan R,
Ayoubi Torik A.Y,
Chada Kiran,
Marchal Kathleen,
Van de Ven Wim J.M,
Petit Marleen M.R
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.05.075
Subject(s) - transcription factor , biology , hmga2 , gene , phenotype , mutant , embryogenesis , microbiology and biotechnology , gene expression , embryonic stem cell , messenger rna , transcription (linguistics) , genetics , microrna , linguistics , philosophy
The developmentally regulated architectural transcription factor, high mobility group A2 (HMGA2), is involved in growth regulation and plays an important role in embryogenesis and tumorigenesis. Little is known, however, about its downstream targets. We performed a search for genes of which expression is strongly altered during embryonic development in two HMGA2‐deficient mouse strains, which display a pygmy‐phenotype, as compared to wild‐type mice. We found that the insulin‐like growth factor II mRNA‐binding protein 2 gene ( IMP2 ), but not its family members IMP1 and IMP3 , was robustly downregulated in mutant E12.5 embryos. Furthermore, we show that wild‐type HMGA2 and its tumor‐specific truncated form have opposite effects on IMP2 expression. Our results clearly indicate that HMGA2 differentially regulates expression of IMP family members during embryogenesis.