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Antioxidant enzymes and redox regulating thiol proteins in malignancies of human lung
Author(s) -
Kinnula Vuokko L,
Pääkkö Paavo,
Soini Ylermi
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.05.045
Subject(s) - catalase , antioxidant , superoxide dismutase , carcinogenesis , enzyme , biochemistry , reactive oxygen species , cell growth , chemistry , biology , microbiology and biotechnology , gene
Oxidants are known to modulate cell proliferation and apoptosis, and induce synthesis of growth factors that play an important role in tumor growth and invasion. Antioxidant enzymes and thiol proteins regulating cellular redox state constitute the major cellular protection against oxidants. Consequently, they are also associated both with carcinogenesis and tumor progression. Superoxide dismutases, glutamate cysteine ligase, catalase, thioredoxins and peroxiredoxins, which are the most important of these enzymes, are expressed in lung malignancies, and especially in pleural mesothelioma. This has consequences not only for tumor behavior but also for resistance of tumor cells to cytotoxic drugs and radiation.