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Microautophagy and macropexophagy may occur simultaneously in Hansenula polymorpha
Author(s) -
Monastryska Iryna,
Sjollema Klaas,
van der Klei Ida J,
Kiel Jan A.K.W,
Veenhuis Marten
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.05.018
Subject(s) - vacuole , yeast , autophagy , peroxisome , chemistry , degradation (telecommunications) , biochemistry , microbiology and biotechnology , nitrogen , methanol , saccharomyces cerevisiae , biophysics , biology , gene , organic chemistry , apoptosis , telecommunications , cytoplasm , computer science
We subjected methanol‐grown cells of wild type Hansenula polymorpha simultaneously to nitrogen depletion and excess glucose conditions. Both treatments induce the degradation of peroxisomes, either selective (via excess glucose) or non‐selective (via nitrogen limitation). Our combined data strongly suggest that both processes occur simultaneously under these conditions. The implications of these findings on studies of autophagy and related transport pathways to the vacuole in yeast are discussed.