Ipaf is upregulated by tumor necrosis factor‐α in human leukemia cells

Ipaf has been associated with apoptosis, cytokine processing, and nuclear factor‐κB activation. Here, we describe that Ipaf is highly expressed in myelomonocytic cells and that the mRNA levels of Ipaf progressively increase during differentiation of CD34 + progenitors to granulocytes and monocytes. Additionally, treatment with tumor necrosis factor‐α and exposure to UV radiation induced the transcriptional activation of Ipaf in human leukemia HL‐60 cells. Thus, Ipaf may contribute to modulate the response of myeloid cells to genotoxic and pro‐inflammatory stimuli.