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Replicative senescence enhances apoptosis induced by pemphigus autoimmune antibodies in human keratinocytes
Author(s) -
Wang Xin,
Brégégère François,
Soroka Yoram,
Frusic-Zlotkin Marina,
Milner Yoram
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.04.083
Subject(s) - pemphigus vulgaris , apoptosis , pemphigus , autoantibody , autoimmune disease , immunology , immunosenescence , senescence , antibody , biology , keratinocyte , programmed cell death , immune system , cell culture , microbiology and biotechnology , genetics
We have recently shown that skin lesions of the autoimmune disease pemphigus vulgaris are associated with Fas‐mediated apoptosis. Here, we describe the induction of the Fas‐dependent apoptosis pathway in cultured keratinocytes by pemphigus vulgaris autoantibodies (PV‐IgG), as seen from a variety of cellular, morphological and biochemical parameters. All apoptotic characters appear stronger and faster in aged cultures than in young, showing increased susceptibility of senescent keratinocytes to PV‐IgG‐mediated apoptotic death and culture lesions. Together with immunosenescence, this phenomenon may explain the late onset of pemphigus disease.