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Functionally and structurally relevant residues of enzymes: are they segregated or overlapping?
Author(s) -
Magyar Csaba,
Tüdős Éva,
Simon István
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.04.070
Subject(s) - flexibility (engineering) , function (biology) , stability (learning theory) , protein stability , enzyme , protein evolution , chemistry , biology , biochemistry , computer science , genetics , mathematics , statistics , machine learning , gene
There is a delicate balance between stability and flexibility needed for enzyme function. To avoid undesirable alteration of the functional properties during the evolutionary optimization of the structural stability under certain circumstances, and vice versa, to avoid unwanted changes of stability during the optimization of the functional properties of proteins, common sense would suggest that parts of the protein structure responsible for stability and parts responsible for function developed and evolved separately. This study shows that nature did not follow this anthropomorphic logic: the set of residues involved in function and those involved in structural stabilization of enzymes are rather overlapping than segregated.