Premium
Chromatin from two classes of platyhelminthes display both protist H1 and higher eukaryote core histones
Author(s) -
Galindo Mario,
Varela Nelson,
Espinoza Ingrid,
Toro Gabriela Cecilia,
Hellman Ulf,
Wernstedt Christer,
Galanti Norbel
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.04.065
Subject(s) - histone , eukaryote , biology , chromatin , fasciola hepatica , histone modifying enzymes , biochemistry , histone h1 , genetics , dna , zoology , gene , genome , helminths
Histones from the parasitic platyhelminthes, Echinococcus granulosus and Fasciola hepatica , were systematically characterized. Core histones H2A, H2B, H3 and H4, which were identified on the basis of amino acid sequencing and mass spectrometry data, showed conserved electrophoretic patterns. Histones H1, identified on the basis of physicochemical properties, amino acid composition and amino acid sequencing, showed divergence, both in their number and electrophoretic mobilities, between the two species and among other organisms. According to these data, core histones but not H1 histones, would be stabilized during evolution at the level of platyhelminthes.