Participation of endoplasmic reticulum and mitochondrial calcium handling in apoptosis: more than just neighborhood? | Zendy

Szabadkai György | Zendy; Rizzuto Rosario | Zendy

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Participation of endoplasmic reticulum and mitochondrial calcium handling in apoptosis: more than just neighborhood?

Author(s) -

Szabadkai György,

Rizzuto Rosario

Publication year - 2004

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2004.04.059

Subject(s) - endoplasmic reticulum , mitochondrion , microbiology and biotechnology , calcium signaling , apoptosis , proteases , calcium , signal transduction , effector , biology , chemistry , biochemistry , enzyme , organic chemistry

Over the past few years, extensive progress has been made in elucidating the role of calcium in the signaling of apoptosis. This has led to the characterization of calcium's role in the induction of apoptosis and in the regulation of effector proteases. In this review, we attempt to summarize the current knowledge regarding a segment of these studies, the interaction between the endoplasmic reticulum (ER) and mitochondria. This interface has been shown to play a crucial role in transferring agonist induced Ca 2+ signals to mitochondria during physiological processes. Recent evidence, however, extended the role of this Ca 2+ transfer to apoptotic pathways, showing that modulation of mitochondrial Ca 2+ uptake from the ER side has a prominent role in modulating cellular fate.

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