Bioimaging TOF‐SIMS: localization of cholesterol in rat kidney sections | Zendy

Nygren Håkan | Zendy; Malmberg Per | Zendy; Kriegeskotte Christian | Zendy; Arlinghaus Heinrich F. | Zendy

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Bioimaging TOF‐SIMS: localization of cholesterol in rat kidney sections

Author(s) -

Nygren Håkan,

Malmberg Per,

Kriegeskotte Christian,

Arlinghaus Heinrich F.

Publication year - 2004

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2004.04.052

Subject(s) - cytoplasm , membrane , cholesterol , basal lamina , chemistry , basal (medicine) , kidney , biophysics , layer (electronics) , materials science , anatomy , biology , biochemistry , endocrinology , ultrastructure , organic chemistry , insulin

Rat kidneys were sectioned by cryoultramicrotomy and dried at room temperature. The samples were covered with a thin silver layer and analyzed in an imaging TOF‐SIMS instrument equipped with a Ga + ‐source. The cholesterol signal showed a high concentration in the nuclear areas of the epithelial cells and a lower concentration over areas representing the basal lamina of renal tubules. A more diffuse distribution of cholesterol was also found over areas representing the cytoplasm or plasma membrane of the epithelial cells.

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