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Expression of estrogen receptor β in prostate carcinoma cells inhibits invasion and proliferation and triggers apoptosis
Author(s) -
Cheng Jennifer,
Lee Eun Jig,
Madison Laird D.,
Lazennec Gwendal
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.04.025
Subject(s) - estrogen receptor , estrogen receptor beta , apoptosis , carcinogenesis , cancer research , estrogen , prostate cancer , suppressor , biology , poly adp ribose polymerase , estrogen receptor alpha , prostate , receptor , medicine , endocrinology , chemistry , cancer , polymerase , gene , biochemistry , breast cancer
The involvement of estrogen receptor beta (ERβ) in prostate carcinogenesis has been hypothesized. Several reports have shown that ERβ expression was decreased when prostate cells undergo neoplastic transformation, suggesting that it could play a tumor‐suppressor role. By restoring ERβ expression in prostatic carcinoma cells by adenoviral delivery, we aimed to test this hypothesis. We observed that ERβ strongly inhibited the invasiveness and the growth of these cells. In addition, ERβ cells were undergoing apoptosis, as shown by quantification of Bax, poly(ADP‐ribose) polymerase and caspase‐3 expression. Our data suggest that ERβ acts as a tumor‐suppressor by its anti‐proliferative, anti‐invasive and pro‐apoptotic properties.