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Neuronal traits are required for glucose‐induced insulin secretion
Author(s) -
Abderrahmani Amar,
Niederhauser Guy,
Plaisance Valérie,
Haefliger Jacques-Antoine,
Regazzi Romano,
Waeber Gérard
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.04.002
Subject(s) - rest (music) , insulin , transcription factor , biology , secretion , endocrinology , repressor , medicine , gene , transcription (linguistics) , microbiology and biotechnology , genetics , linguistics , philosophy
The transcriptional repressor RE1 silencer transcription factor (REST) is an important factor that restricts some neuronal traits to neurons. Since these traits are also present in pancreatic β‐cells, we evaluated their role by generating a model of insulin‐secreting cells that express REST. The presence of REST led to a decrease in expression of its known target genes, whereas insulin expression and its cellular content were conserved. As a consequence of REST expression, the capacity to secrete insulin in response to mitochondrial fuels, a particularity of mature β‐cells, was impaired. These data provide evidence that REST target genes are required for an appropriate glucose‐induced insulin secretion.