Premium
Evidence that human genes of modular proteins have retained significantly more ancestral introns than their fly or worm orthologues
Author(s) -
Bányai László,
Patthy László
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.03.088
Subject(s) - intron , biology , exon , gene , chordate , genetics , genome , lineage (genetic) , caenorhabditis elegans , human genome
Comparison of the exon–intron structures of human, fly and worm orthologues of mosaic genes assembled from class 1‐1 modules by exon‐shuffling has revealed that human genes retained significantly more of the original inter‐module introns than their protostome orthologues. It is suggested that the much higher rate of intron loss in the worm‐ and insect lineages than in the chordate lineage reflects their greater tendency for genome compaction.