Maternal phthalate exposure associated with decreased testosterone/LH ratio in male offspring during mini-puberty. Odense Child Cohort | Zendy

Anna-Patricia Muerköster | Zendy; Hanne Frederiksen | Zendy; Anders Juul | Zendy; AnnaMaria Andersson | Zendy; Richard Christian Jensen | Zendy; Dorte Glintborg | Zendy; Henriette Boye Kyhl | Zendy; Marianne Andersen | Zendy; Clara Amalie Gade Timmermann | Zendy; Tina Kold Jensen | Zendy

Open Access

Maternal phthalate exposure associated with decreased testosterone/LH ratio in male offspring during mini-puberty. Odense Child Cohort

Author(s) -

Anna-Patricia Muerköster,

Hanne Frederiksen,

Anders Juul,

AnnaMaria Andersson,

Richard Christian Jensen,

Dorte Glintborg,

Henriette Boye Kyhl,

Marianne Andersen,

Clara Amalie Gade Timmermann,

Tina Kold Jensen

Publication year - 2020

Publication title -

environment international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.582

H-Index - 191

eISSN - 1873-6750

pISSN - 0160-4120

DOI - 10.1016/j.envint.2020.106025

Subject(s) - phthalate , endocrinology , offspring , medicine , testosterone (patch) , luteinizing hormone , androstenedione , dehydroepiandrosterone sulfate , follicle stimulating hormone , physiology , androgen , pregnancy , chemistry , hormone , biology , organic chemistry , genetics

Even in these low exposed children, we found a significant decrease in T/LH ratio during mini-puberty in boys prenatally exposed to phthalates, which may suggest impairment of Leydig cells. The children will be followed as they approach adrenarche and pubarche in order to assess if long-term adverse effects persist.

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