Open AccessDiffusion-weighted MRI and apparent diffusion coefficient in differentiation of benign from malignant solitary thyroid nodule
Author(s) -
Hossam M. Abdel-Rahman,
Mohamed Hamed Abowarda,
Salah Mansour Abdel-Aal
Publication year - 2016
Publication title -
the egyptian journal of radiology and nuclear medicine /the egyptian journal of radiology and nuclear medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.19
H-Index - 13
eISSN - 2090-4762
pISSN - 0378-603X
DOI - 10.1016/j.ejrnm.2016.08.022
Subject(s) - medicine , thyroid nodules , nodule (geology) , thyroid , effective diffusion coefficient , cutoff , nuclear medicine , diffusion mri , radiology , pathology , magnetic resonance imaging , biology , paleontology , physics , quantum mechanics
Objective: The aim of this study was to assess the ability of DWI and ADC to differentiate benign from malignant solitary thyroid nodule.Patients and methods: This prospective study was done on 60 patients with solitary thyroid nodule. DW- MRI was performed on all subjects at b values of 0, 500 and 1000 mm2/s. The mean ADC values of solitary thyroid nodules were measured for b values of 500 and 1000 s/mm2.Results: The ADC value of benign solitary thyroid nodules ranged from 1.56 to 2.28 × 10−3 mm2/s (b = 1000 s/mm2) and from 1.64 to 2.70 × 10−3 mm2/s (b = 500 s/mm2). The ADC value of malignant solitary thyroid nodules ranged from 0.54 to 1.47 × 10−3 mm2/s (b = 1000 s/mm2) and from 0.61 to 1.56 × 10−3 mm2/s (b = 500 s/mm2). The mean ADC value for malignant nodules was significantly lower than that for benign nodules (P = 0.000). ADC value of 1.5 × 10−3 mm2/s was used as a cutoff value for differentiation of benign from malignant thyroid nodules.Conclusions: DWI is a powerful tool for the differentiation of benign and malignant nodules and for assessing the functional activity of the thyroid gland, and ADC at b-1000 is more accurate in evaluation of solitary thyroid nodule in comparison with b-500