Open AccessT2 ∗ magnetic resonance imaging: A non-invasive biomarker of brain iron content in children with attention-deficit/hyperactivity disorder
Author(s) -
Bothina Mohamed Hasaneen,
Moustafa Sarhan,
Sieza Samir,
Mohamed El-Assmy,
Amal Abdelsattar Sakrana,
Germeen Albair Ashamalla
Publication year - 2017
Publication title -
the egyptian journal of radiology and nuclear medicine /the egyptian journal of radiology and nuclear medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.19
H-Index - 13
eISSN - 2090-4762
pISSN - 0378-603X
DOI - 10.1016/j.ejrnm.2016.08.001
Subject(s) - attention deficit hyperactivity disorder , magnetic resonance imaging , medicine , biomarker , audiology , psychology , psychiatry , radiology , biology , biochemistry
PurposeThe aims of this study were the followings: First: To compare brain iron content in children with Attention-Deficit/Hyperactivity Disorder (ADHD) and healthy control subjects, estimated by T2∗ MRI value and its reciprocal R2∗. Second: To assess the association between brain iron content and distinct types of ADHD (predominantly inattentive, predominantly hyperactive/impulsive, or combined). Third: To test the ability of T2∗ MRI to grade the severity of ADHD.Patients and methods35 children (17 ADHD patients and 18 healthy non-ADHD controls) underwent T2∗-MRI to assess brain iron content. R2∗ value is calculated for both thalami.ResultsADHD group showed significantly lower R2∗ (mean 14.9s−1±1.3) value when compared to control group (mean R2∗ 16.6s−1±0.9) (p=<0.001). Best cutoff value for R2∗ was 15.65s−1, and R2∗ less than 15.65s−1 showed good AUC for prediction of ADHD. Combined ADHD type showed significantly lower R2∗ when compared to inattentive type (p=0.033 respectively). No significant correlations were found between R2∗ value and severity of ADHD.ConclusionT2∗ MRI represents a reliable non-invasive tool for probing brain iron contents. Lower R2∗ values correlate with ADHD type but not with ADHD severity