Open AccessCT perfusion in evaluation of post therapy cervical lymphoma
Author(s) -
Nihal M. Batouty,
Amina Sultan,
N Shams,
Nahed Abd El-Gaber,
Mahmoud A. Rashed
Publication year - 2016
Publication title -
the egyptian journal of radiology and nuclear medicine /the egyptian journal of radiology and nuclear medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.19
H-Index - 13
eISSN - 2090-4762
pISSN - 0378-603X
DOI - 10.1016/j.ejrnm.2016.07.012
Subject(s) - medicine , perfusion , nuclear medicine , lymphoma , perfusion scanning , lymph , blood flow , lymph node , blood volume , gastroenterology , pathology
ObjectiveCompare CT perfusion between responders and non-responders in patients with residual cervical nodes after lymphoma treatment.Subjects and methodsTwenty-seven patients with treated pathologically proved lymphoma were included in this prospective study, divided into two groups: responders (n. 15) and non-responders to treatment (n. 12). Blood flow (BF), blood volume (BV), mean transit time (MTT) and permeability (PS) were determined using CT perfusion. Lymph nodes sizes were measured (short axis).ResultsBF, BV and PS were significantly higher in non-responders group [93.3 (65.3–111) ml/min/100g, 6.3 (5.2–8) ml/100g and 18.9 (14.5–25.1) ml/min/100g respectively] as compared to responders group [54 (43.8–77.5) ml/min/100g, 4.1 (2.2–4.8) ml/100g and 9.4 (7.5–14.5) ml/min/100g respectively], [p 0.019, 0.004 and 0.004 respectively]. MTT had a trend to be low in non-responders group, but did not reach statistical significance (p 0.305). Cutoff value for BF, BV and PS was 59.5 ml/min/100g, 3.6ml/100g and 11.1ml/min/100g respectively, 92% sensitivity for the three parameters and specificity 67%, 47% and 73% respectively. Lymph node sizes had no relation to the perfusion parameter values.ConclusionCT perfusion is a functional imaging tool with promising results in differentiating between responders and non-responders in treated lymphoma patients, using BF, BV and PS