Open AccessAdded value of combined 18F-FDG PET/CT for detection of osseous metastases in cancer patients
Author(s) -
Susan Adil Ali,
Yasser I. Abd Elkhalek
Publication year - 2016
Publication title -
the egyptian journal of radiology and nuclear medicine /the egyptian journal of radiology and nuclear medicine
Language(s) - English
Resource type - Journals
eISSN - 2090-4762
pISSN - 0378-603X
DOI - 10.1016/j.ejrnm.2016.03.006
Subject(s) - medicine , radiology , pet ct , nuclear medicine , biopsy , lesion , predictive value , metastasis , cancer , positron emission tomography , pathology
AbstractPurposeThe goal of the study was to illustrate the added value of combined 18F-FDG PET/CT over isolated CT for detection of osseous metastases in cancer patients.Patients and methodsThe study included 53 patients divided into five groups of primary malignancies. 18F-PET/CT scans were performed. In this study, a lesion based analysis was performed in detailed retrograde matter for a total of 386 detected osseous lesions on CT and fused images of 18F-PET/CT. Statistical analysis including specificity, Sensitivity, negative predictive value (NPV) and positive predictive value (PPV) of each of these modalities was calculated. A final diagnosis of metastasis was confirmed by biopsy or by further clinical and radiologic workup.ResultsAccording to lesion based analysis, the 18F-PET/CT showed 100% sensitivity, 80.8% specificity, 98.6% PPV, 100% NPV and 98.7% accuracy compared with 93.9%, 34.6%, 95.2%, 29% and 89.9%, respectively, for CT. Significant improvement of the sensitivity and specificity was found in combined 18F-PET/CT than in CT alone.ConclusionCombined 18-F FDG PET/CT significantly improves the sensitivity and specificity of isolated CT for the detection of osseous metastases