Open AccessAssessment of postoperative local and distant recurrence in colorectal cancer patients: Comparison between PET/CT and CECT
Author(s) -
Ahmed Hussein,
Mohamed Nassef
Publication year - 2016
Publication title -
the egyptian journal of radiology and nuclear medicine /the egyptian journal of radiology and nuclear medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.19
H-Index - 13
eISSN - 2090-4762
pISSN - 0378-603X
DOI - 10.1016/j.ejrnm.2016.02.002
Subject(s) - medicine , radiology , colorectal cancer , pathological , distant metastasis , nuclear medicine , lesion , radiation therapy , gold standard (test) , metastasis , cancer , surgery
Objective: To assess the diagnostic performance of 18F-FDG PET/CT scan in the detection of recurrent disease in CRC patients who have suspected local and/or distant recurrent disease compared to contrast enhanced CT scan (CECT).Material and method: 96 CRC treated patients with suspected recurrence were examined by CECT and 18F-FDG PET/CT. Pathological results, clinical or imaging follow-up, or the responsiveness of the lesion to the treatment with chemotherapy or radiation therapy were reviewed for gold standard.Results: Recurrent or metastatic disease was found in 74 (77.1%) of 96 patients. Calculated sensitivity, specificity, and accuracy of 18F-FDG PET/CT were 92%, 72.7%, and 88.5%. The specificity of 18F-FDG PET/CT was statistically significantly better than that of CECT as it can reduce the false positive results of CECT in 13 patients, however regarding the sensitivity.18F-FDG PET/CT showed better value but without statistical significance.Conclusion: 18F-FDG PET/CT is a better method to evaluate postoperative CRC patients with suspected tumor recurrence or distant metastasis than CT with significantly higher specificity