Open AccessDifferentiation between high-grade gliomas and metastatic brain tumors using Diffusion Tensor Imaging metrics
Author(s) -
Lamiaa El-Serougy,
Ahmed Abdel Khalek Abdel Razek,
Amani Ezzat Mousa,
Hany Eldawoody,
Ahmad El-Morsy
Publication year - 2015
Publication title -
the egyptian journal of radiology and nuclear medicine /the egyptian journal of radiology and nuclear medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.19
H-Index - 13
eISSN - 2090-4762
pISSN - 0378-603X
DOI - 10.1016/j.ejrnm.2015.08.005
Subject(s) - diffusion mri , medicine , fractional anisotropy , effective diffusion coefficient , nuclear medicine , glioma , metastatic tumor , edema , pathology , metastasis , radiology , magnetic resonance imaging , cancer research , cancer
The aim of this work was to differentiate between high-grade gliomas and metastatic brain tumors using diffusion tensor derived metrics in the enhancing tumor and peri-tumoral regions.Patients & methods: Prospective study was done on 36 patients with provisional MRI diagnosis of high grade gliomas WHO grade III & IV versus metastatic brain tumors, examination was done on 1.5 tesla scanner, patients were divided into two groups based on pathology results, the fraction anisotropy (FA), mean diffusivity (MD), linear coefficient (CL), planer coefficient (CP) and spherical coefficient (CS) were measured in the enhancing tumor parts and immediate peri-tumoral edema and results were compared between the two groups.Results: Values of FA, CL and CP measured in the peri-tumoral edema were significantly high in the metastatic than primary high malignant glial tumors with high specificity (100%) of the CP and high sensitivity of the CL (76.5%) among the three significant values, and no significant differences in the values of MD and CS. The values of the five metrics measured in the enhancing tumor parts showed no significant differences between the two groups.Conclusion: Brain metastasis and high-grade gliomas can be differentiated using DTI derived FA, CL and CP measured in the peri-tumoral region