Open AccessHepatic iron deposition in patients with sickle cell disease: Role of breath-hold multiecho T2∗-weighted MRI sequence
Author(s) -
Fatma Mohamed Awad,
Shereen Ahmed Alshazly
Publication year - 2014
Publication title -
the egyptian journal of radiology and nuclear medicine /the egyptian journal of radiology and nuclear medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.19
H-Index - 13
eISSN - 2090-4762
pISSN - 0378-603X
DOI - 10.1016/j.ejrnm.2014.05.002
Subject(s) - medicine , liver parenchyma , magnetic resonance imaging , liver biopsy , hemosiderosis , grading (engineering) , pathology , biopsy , radiology , civil engineering , engineering
The purpose of this study is to detect the role of breath-hold multiecho T2∗-weighted MRI, in quantification of hepatic iron deposition in patients with sickle cell disease.Methods: Thirty-seven patients underwent 1.5-T MRI of the liver that included a multiecho T2∗-weighted sequence. Hepatic T2∗ iron grading was done for each patient by placing regions of interest in the hepatic parenchyma. Hepatic T2∗ values were correlated with histopathological iron grade. Liver biopsy was done for all patients. Written consent was obtained from all patients prior to MRI studies.Results: Thirty-two patients (86.5 %) had evidence of hepatic iron deposition on histopathological examination, including eight (25%) with grade 3, eleven (34%) with grade 2 and thirteen patients (41%) with grade 1.Patients with negative iron deposition histologically, had T2∗ values ranging from 28–32 ms. For the patients with positive hepatic iron deposition, hepatic T2∗ decreased with increasing iron grade.Statistical analysis showed that for differentiation of hepatic iron deposition grade 3 from grades 1 and 2, hepatic T2∗ less than 13 ms had a sensitivity and specificity of 100 % and 98%, respectively.Conclusion: Breath-hold multiecho T2∗-weighted MRI sequence offers an accurate estimation of hepatic iron deposition