Open AccessMR spectroscopy and diffusion MR imaging in characterization of common sellar and supra-sellar neoplastic lesions
Author(s) -
Faten Fawzy Mohammad,
Doaa Ibrahim Hasan,
Mohamed Gouda Ammar
Publication year - 2014
Publication title -
the egyptian journal of radiology and nuclear medicine /the egyptian journal of radiology and nuclear medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.19
H-Index - 13
eISSN - 2090-4762
pISSN - 0378-603X
DOI - 10.1016/j.ejrnm.2014.04.012
Subject(s) - craniopharyngioma , medicine , germinoma , meningioma , diffusion mri , in vivo magnetic resonance spectroscopy , radiology , nuclear medicine , effective diffusion coefficient , pituitary adenoma , magnetic resonance imaging , pathology , radiation therapy , adenoma
BackgroundMR spectroscopy and diffusion-weighted imaging are useful non invasive imaging modalities used for characterization of different sellar and suprasellar lesions.Patient and methodsWe studied 30 cases of suprasellar SOLs (as proved by conventional MRI), MRS and DWI. Our findings were correlated with histopathological analysis after surgical resection.ResultsThree false positive cases in which cMRI give diagnosis mismatched with that obtained after adding the MRS findings and ADC values. MR spectrum type IIC is found in macroadenoma, craniopharyngioma, meningioma and germinoma with characteristic broad lipid peak in the second and forth types and elevated alanine peak in meningioma. Glioma had MRS appearance of type IIB. Simple differentiation between tumor types were achieved by the mean ADC values which were statistically significant (p<0.001) when correlated to the histological diagnosis. When the ADC value of 0.6×10−3mm2/s this strongly points to macroadenoma, ADC value of 1.05×10−3mm2/s in meningiomas, ADC value 1.88 8×10−3mm2/s strongly points to craniopharyngioma, while gliomas and germinoma had ADC values 1.6×10−3mm2/s and 1.0×10−3mm2/s respectively.ConclusionMR spectroscopy and DWMRI are considered important diagnostic tools complementary to cMRI in pre-surgical evaluation and discrimination between different sellar and suprasellar lesions