Open AccessCan contrast enhanced mammography solve the problem of dense breast lesions?
Author(s) -
Omnia Mokhtar,
Sheryhan Mahmoud
Publication year - 2014
Publication title -
the egyptian journal of radiology and nuclear medicine /the egyptian journal of radiology and nuclear medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.19
H-Index - 13
eISSN - 2090-4762
pISSN - 0378-603X
DOI - 10.1016/j.ejrnm.2014.04.007
Subject(s) - medicine , mammography , digital mammography , radiology , breast ultrasound , ultrasound , nuclear medicine , breast cancer , cancer
ObjectiveTo assess the diagnostic accuracy of dual-energy contrast-enhanced digital mammography (CEDM) as an adjunct to mammography (MX) vs. MX alone and vs. mammography plus ultrasound (US) in dense breasts.Materials and methods60 women with suspected findings on MX and/or US underwent CEDM. A pair of low- and high-energy images was acquired using a modified full-field digital mammography system. Exposures were taken in MLO at 2min and in CC at 4min after the injection of 1.5ml/kg of an iodinated contrast agent. Sensitivity, specificity, and area under the ROC curve were estimated.ResultsThe results from pathology identified 16 benign and 44 malignant cases. Areas under the ROC curves were significantly superior for MX+CEDM than it was for MX alone using BI-RADS. Sensitivity was higher for MX+CEDM than it was for MX (97.7% vs. 93.2%) with no loss in specificity. The lesion size was closer to the histological size for CEDM. All 12 histologically proven multifocal lesions were correctly detected by MX+CEDM vs. 6 and 8 lesions by MX and US respectively.ConclusionInitial clinical results show that CEDM has better diagnostic accuracy than mammography alone and mammography+ultrasound especially in dense breasts