Open AccessCan diffusion weighted image and apparent diffusion coefficient (ADC) differentiate benign from malignant cervical adenopathy?
Author(s) -
Ahmad S. Ragheb,
Hossam Mansour Abdel Rahman,
Ahmed Rageh Ismail,
Nashwa Nawar
Publication year - 2014
Publication title -
the egyptian journal of radiology and nuclear medicine /the egyptian journal of radiology and nuclear medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.19
H-Index - 13
eISSN - 2090-4762
pISSN - 0378-603X
DOI - 10.1016/j.ejrnm.2014.01.016
Subject(s) - medicine , cervical lymphadenopathy , effective diffusion coefficient , radiology , diffusion mri , cervical lymph nodes , lymph node , ultrasound , prospective cohort study , pathology , magnetic resonance imaging , metastasis , cancer , disease
AbstractBackgroundCervical adenopathy is a common problem and the differentiation of benign and malignant node is of crucial importance for therapy management.ObjectiveThis prospective study aimed to know if Diffusion weighted images (DWI) and apparent diffusion coefficient (ADC) can differentiate benign from malignant cervical lymphadenopathy.Patients and methodsThirty patients with cervical adenopathy were included in this study. Doppler ultrasound, DWI and ADC maps were automatically reconstructed and used for the measurement of ADC values.ResultsThe sensitivity and specificity of the RI cut-off value <0.69 in differentiation between benign and malignant cervical L.Ns was 88.8% and 71.4%, respectively. The optimal ADC cut off value for differentiation between benign and malignant lymph nodes was ⩽1.0×10−3mm2/s with an accuracy 96.7%, a sensitivity 100%, a specificity 88.9%, PPV 95.4% and NPV 100% and statistically significant P-value=0.000.ConclusionDWI and ADC were useful for differentiation between benign and malignant cervical lymphadenopathy and recommended to decrease the need of invasive biopsies. However, CDUS techniques can be used as preliminary technique but, they had potential pitfalls in diagnosis of malignant cervical lymphadenopathy cases