Open AccessMalignant breast tumours: Correlation of apparent diffusion coefficient values using diffusion-weighted images and dynamic contrast-enhancement ratio with histologic grading
Author(s) -
Ghada K. Gouhar,
Mona A. El-Hariri,
Wael E Lotfy
Publication year - 2011
Publication title -
the egyptian journal of radiology and nuclear medicine /the egyptian journal of radiology and nuclear medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.19
H-Index - 13
eISSN - 2090-4762
pISSN - 0378-603X
DOI - 10.1016/j.ejrnm.2011.08.003
Subject(s) - medicine , grading (engineering) , effective diffusion coefficient , nuclear medicine , diffusion mri , magnetic resonance imaging , breast mri , breast cancer , correlation , radiology , cancer , mammography , mathematics , civil engineering , geometry , engineering
PurposeTo evaluate the correlation of the apparent diffusion coefficient (ADC) using diffusion weighted imaging (DWI) and early/delayed enhancement (E/D) ratio using dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) with histological grading in malignant breast lesions.Material and methodsThirty-one women with 34 histopathologically proved malignant breast lesions underwent MRI within 2weeks prior to surgery. MRI examination included T1 and T2W sequences, DWI and DCE-MRI. ADC values and E/D ratios are correlated with the histological grades.ResultsThe mean ADC of the malignant lesions was 0.85±0.12×10−3mm2/s. The mean ADC values of grade I, II and III were 0.96±0.12×10−3mm2/s, 0.87±0.07×10−3mm2/s and 0.75±0.12×10−3mm2/s, respectively. Tumours with higher grade showed significantly lower ADC value (p=0.0001) compared with lower grade and there is an inverse correlation between ADC value and histological grade (r=−0.62, p-value=0.0001). The mean E/D ratio for grade I, II and III tumours were 0.98±0.04, 1.01±0.05 and 1.07±0.08, respectively. Tumours with higher grade showed significantly higher E/D ratio (p=0.005) compared with lower grade and there was a direct correlation between E/D ratio and histological grade (r=0.44, p=0.008).ConclusionDWI is a useful diagnostic parameter with significantly higher correlation with the histological grade of breast cancer than DCE MRI, which is an important factor for proper treatment selection