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Activation of anterior cingulate cortex produces inhibitory effects on noxious mechanical and electrical stimuli‐evoked responses in rat spinal WDR neurons
Author(s) -
Mal JiuHong,
Xiaol TieHui,
Changl ChongWang,
Gaol Li,
Wangl XueLian,
Gaol GuoDong,
Yul YaoQing
Publication year - 2011
Publication title -
european journal of pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.305
H-Index - 109
eISSN - 1532-2149
pISSN - 1090-3801
DOI - 10.1016/j.ejpain.2011.04.003
Subject(s) - stimulation , noxious stimulus , neuroscience , spinal cord , inhibitory postsynaptic potential , electrophysiology , premovement neuronal activity , nociception , anterior cingulate cortex , chemistry , evoked potential , medicine , anesthesia , psychology , receptor , cognition
In present study, in vivo electrophysiological techniques were applied to examine the effects of anterior cingulate cortex (ACC) activation on mechanical and electrical stimuli‐evoked responses in rat spinal cord wide‐dynamic‐range (WDR) neurons. We found that bilateral ACC electrical stimulation (100 Hz, 20 V, 20 s) had different effects on neuronal responses to brush, pressure and pinch stimuli (10 s). The brush‐evoked neuronal responses at baseline, post 1 min and post 5 min were 60.8±15.0, 59.2±15.4 and 60.0±19.3 spikes/10 s, respectively ( n =10, P >0.05 vs. baseline). The pressure‐evoked neuronal responses at baseline, post 1 min and post 5 min were 77.8±11.9, 38.0±7.8 and 45.8±7.6 spikes/10 s, respectively ( n =10, P <0.05 vs. baseline). The pinch‐evoked neuronal responses at baseline, post 1 min and post 5 min were 137.6±16.7, 62.6±17.5 and 68.8±15.0 spikes/10 s, respectively ( n =10, P <0.05 vs. baseline). Furthermore, ACC stimulation generated distinct effects on the different components of wind‐up response. The total numbers of late response (LR) and after‐discharge (AD), but not early response (ER), significantly decreased. Collectively, the present study demonstrated that short‐term ACC activation could generate long‐term inhibitory effects on the responses of WDR neurons to noxious mechanical (pressure and pinch) and electrical stimuli. The results indicated that ACC activation could negatively regulate noxious information ascending from spinal cord with long‐term effect, providing potential neuronal substrate for the modulation of ACC activation on nociception.