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Neonatal arthritis disturbs sleep and behaviour of adult rat offspring and their dams
Author(s) -
Roizenblatt Suely,
Andersen Monica L.,
Bignotto Magda,
D'Almeida Vania,
Martins Paulo J.F.,
Tufik Sergio
Publication year - 2010
Publication title -
european journal of pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.305
H-Index - 109
eISSN - 1532-2149
pISSN - 1090-3801
DOI - 10.1016/j.ejpain.2010.03.008
Subject(s) - melatonin , offspring , medicine , corticosterone , endocrinology , prolactin , serotonin , anxiety , sleep (system call) , psychology , hormone , pregnancy , biology , psychiatry , genetics , receptor , computer science , operating system
This study aims to evaluate the impact of neonatal arthritis on adult pain threshold, sleep and general behaviours in rats and their lactating dams. Male pups were injected in the hind paw with complete Freund's adjuvant or saline on postnatal day (PN) 1. After weaning, dams were tested for anxiety, sleep recording or hormone profiling (ACTH, corticosterone and prolactin) and brain sampling (pineal melatonin and hippocampus serotonin). At adulthood (PN90), distinct subgroups of neonatal arthritic (AR) and control rats (CR) were also assessed for anxiety and pain thresholds, sleep recording, and blood/brain sampling. Compared to their respective controls at PN12, dams of arthritic rats (DAR) showed a longer latency in expressing pup retrieval and dam–pup interaction. DAR and AR showed a lower pain threshold, anxiety‐like behaviour, and sleep fragmentation. Compared to controls, DAR displayed longer sleep latency, reduced paradoxical sleep latency and sleep efficiency, a decrease in prolactin and serotonin levels and increased melatonin levels. This model of unilateral hindpaw inflammation has a wide range of long‐term effects in both lactating dams and their adult offspring.