Premium
The role of brain‐derived neurotrophic factor in different animal models of neuropathic pain
Author(s) -
Vanelderen Pascal,
Rouwette Tom,
Kozicz Tamas,
Roubos Eric,
Zundert Jan,
Heylen Rene,
Vissers Kris
Publication year - 2010
Publication title -
european journal of pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.305
H-Index - 109
eISSN - 1532-2149
pISSN - 1090-3801
DOI - 10.1016/j.ejpain.2009.09.006
Subject(s) - neuropathic pain , neurotrophic factors , brain derived neurotrophic factor , neurotrophin , neuroscience , nerve growth factor , medicine , sciatic nerve , neurotrophin 3 , anesthesia , psychology , receptor
Even in present day pain therapy, neuropathic pain remains a challenge for clinicians to treat and a challenge for researchers to investigate. Different animal models have been developed to mimic neuropathic pain. Neurotrophins such as nerve growth factor, brain‐derived neurotrophic factor and neurotrophin 3 have been studied extensively in these models, yet few review articles concerning brain‐derived neurotrophic factor have been published. This article reassesses the literature concerning brain‐derived neurotrophic factor expression in the sciatic nerve chronic constriction injury model, the sciatic nerve transection model, the spinal nerve ligation model and the spinal nerve transection model and discusses differences in regulation of brain‐derived neurotrophic factor between these models and their causality with neuropathic pain.