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Dopamine receptors in the anterior insular cortex modulate long‐term nociception in the rat
Author(s) -
Coffeen Ulises,
LópezAvila Alberto,
OrtegaLegaspi J. Manuel,
Ángel Rosendo,
LópezMuñoz Francisco J.,
Pellicer Francisco
Publication year - 2008
Publication title -
european journal of pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.305
H-Index - 109
eISSN - 1532-2149
pISSN - 1090-3801
DOI - 10.1016/j.ejpain.2007.08.008
Subject(s) - nociception , dopaminergic , dopamine receptor , agonist , dopamine , chemistry , endocrinology , medicine , sch 23390 , dopamine receptor d1 , receptor , neuroscience , pharmacology , psychology
The rostral agranular insular cortex (RAIC) receives dopaminergic projections from the mesolimbic system, which has been involved in the modulation of nociceptive processes. In this study we determined the contribution of dopamine D 1 and D 2 receptors in the RAIC regarding nociception processing in a neuropathic pain model, as well as inflammatory articular nociception measured as pain‐induced functional impairment in the rat (PIFIR). Microinjection of vehicle or substances into the RAIC was performed after the induction of nociception. The groups were treated with: a dopamine D 1 receptor antagonist (SCH‐23390), a dopamine D 1 receptor agonist (SKF‐38393), a dopamine D 2 receptor agonist (TNPA) and a dopamine D 2 receptor antagonist (spiperone). Chronic nociception, induced by denervation, was measured by the autotomy score in which onset and incidence were also determined. The SCH‐23390 and TNPA groups showed a decrease in the autotomy score and a delay on the onset as compared to control, whereas the PIFIR groups did not show statistical differences. This work shows the differential role of dopamine receptors within the RAIC in which the activation of D 2 or the blockade of D 1 receptors elicit antinociception.