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Increased seroprevalence of parvovirus B 19 IgG in complex regional pain syndrome is not associated with antiendothelial autoimmunity
Author(s) -
Gross Oliver,
Tschernatsch Marlene,
Bräu Michael E.,
Hempelmann Gunter,
Birklein Frank,
Kaps Manfred,
Madlener Katharina,
Blaes Franz
Publication year - 2007
Publication title -
european journal of pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.305
H-Index - 109
eISSN - 1532-2149
pISSN - 1090-3801
DOI - 10.1016/j.ejpain.2006.01.006
Subject(s) - autoantibody , parvovirus , pathogenesis , medicine , autoimmunity , immunology , complex regional pain syndrome , seroprevalence , etiology , antibody , serology , virus , physical therapy
The etiology of complex regional pain syndrome (CRPS) is unclear yet. Recently autoantibodies and antecedent viral infections have been discussed to be involved in the pathogenesis of CRPS. We investigated sera from 39 CRPS patients and healthy controls for parvovirus B19 IgG and the occurrence of antiendothelial autoantibodies (AECA). CRPS patients showed a higher seroprevalence of parvovirus B19 IgG than controls ( p <0.01). All CRPS 2 patients were positive. 10.2% of the CRPS patients and 10.0% of the controls had AECA (n.s.) and AECA were not associated with parvovirus B19 seropositivity. Our findings suggest the involvement of parvovirus B19, but not autoantibody‐mediated endothelial cell damage, in the pathogenesis of CRPS.