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Opioids and central sensitisation: II. Induction and reversal of hyperalgesia
Author(s) -
Ruscheweyh Ruth,
Sandkühler Jürgen
Publication year - 2005
Publication title -
european journal of pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.305
H-Index - 109
eISSN - 1532-2149
pISSN - 1090-3801
DOI - 10.1016/j.ejpain.2004.05.011
Subject(s) - hyperalgesia , neuroscience , anesthesia , pharmacology , medicine , psychology , nociception , receptor
Opioids are powerful analgesics when used to treat acute pain and some forms of chronic pain. In addition, opioids can pre‐empt some forms of central sensitization {Sandkühler and Ruscheweyh, Eur. J. Pain, in press, doi:10.1016/j.ejpain.2004.05.012}. Here we review evidence that opioids may also induce and perhaps reverse some forms of central sensitization.