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Opioids in neuropathic pain: clues from animal studies
Author(s) -
Dickenson Anthony H.,
Suzuki Rie
Publication year - 2005
Publication title -
european journal of pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.305
H-Index - 109
eISSN - 1532-2149
pISSN - 1090-3801
DOI - 10.1016/j.ejpain.2004.05.004
Subject(s) - neuropathic pain , medicine , opioid , nerve injury , anesthesia , neuroscience , intensive care medicine , psychology , receptor
For many years the clinical consensus was that opioids were ineffective in neuropathic pain. However this view is changing and here we discuss the mechanisms of opioid analgesia in terms of the changes that can occur in preclinical models of nerve injury. We argue that opioid mechanisms can be perturbed by neuropathy but in most cases these negative influences can be overcome by dose‐escalation.