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Long‐term prognosis of the transient left ventricular dysfunction syndrome (Tako‐Tsubo cardiomyopathy): Focus on malignancies
Author(s) -
Burgdorf Christof,
Kurowski Volkhard,
Bonnemeier Hendrik,
Schunkert Heribert,
Radke Peter Walter
Publication year - 2008
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1016/j.ejheart.2008.07.008
Subject(s) - medicine , malignancy , hazard ratio , odds ratio , cardiology , confidence interval , myocardial infarction , heart failure , cardiomyopathy , cohort
Background: The pathophysiology and long‐term prognosis of the transient left ventricular dysfunction syndrome (LVDS, Tako‐Tsubo cardiomyopathy) is largely unknown. Aims: To investigate the prevalence of malignancies and long‐term mortality in patients with LVDS. Methods and results: Fifty patients with LVDS (47 females and 3 men, age 70±10 years) and 50 age‐ and gender‐matched control patients with acute anterior myocardial infarction (MI) were evaluated. Nine patients (18%) with LVDS and 3 patients (6%) with MI had a previous history of malignancy at the time of the index event. On follow‐up (2.9±1.6 years), 7 malignancies were newly diagnosed in the LVDS cohort whereas no new case of malignancy was found in the control group ( p =0.01, odds ratio 16.95, 95% confidence interval [CI] 1.93–304.60). Overall mortality during follow‐up did not differ significantly between both groups (hazard ratio 1.44 for death in LVDS patients, 95% CI 0.52–3.95, p =0.49); however, of those patients who died, cardiac deaths were more frequent in patients with MI (100% versus 11%in patients with LVDS, p <0.001). Conclusions: Our data suggest an association of LVDS with malignancies, potentially as a result of paraneoplastic phenomena. Long‐term prognosis of patients with LVDS is no better than in patients with acute MI.