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Effect of atrial natriuretic peptide on adiponectin in patients with heart failure
Author(s) -
Tanaka Toshinari,
Tsutamoto Takayoshi,
Sakai Hiroshi,
Nishiyama Keizo,
Fujii Masanori,
Yamamoto Takashi,
Horie Minoru
Publication year - 2008
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1016/j.ejheart.2008.02.005
Subject(s) - adiponectin , medicine , atrial natriuretic peptide , heart failure , natriuretic peptide , endocrinology , concomitant , brain natriuretic peptide , cardiology , obesity , insulin resistance
Abstract Background: The adipocyte‐specific cytokine adiponectin, has cardioprotective effects, correlates with endogenous cardiac natriuretic peptides and adipocyte has guanylyl cyclase‐A receptors of natriuretic peptides. Aims: To evaluate the effect of carperitide (atrial natriuretic peptide; ANP) on plasma adiponectin in patients with heart failure. Methods and results: Seventy‐five patients admitted to our hospital with decompensated heart failure were randomised (1:2) to nitroglycerin (group I: n = 23) or carperitide infusion (group II: n = 52). Blood samples were collected at baseline and after 7 days. Plasma levels of total and high‐molecular weight (HMW) adiponectin, ANP and brain natriuretic peptide (BNP) were measured. There were no differences in baseline characteristics between the two groups. In group I, plasma levels of total and HMW adiponectin were significantly decreased (21.1±2.5 to 18.6±2.5 μg/mL, p < 0.05, 12.3±1.8 to 10.8±1.7 μg/mL, p < 0.05, respectively) concomitant with the decrease in plasma levels of ANP and BNP. In group II, plasma levels of total and HMW adiponectin were significantly increased (17.3±1.3 to 19.7±1.6 μg/mL, p < 0.0001, 9.8±1.0 to 10.5±1.0 μg/mL, p < 0.05, respectively) concomitant with the increase in ANP. Conclusions: These findings indicate that carperitide infusion increases plasma levels of total and HMW adiponectin in patients with heart failure.