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Anaemia and renal dysfunction are independently associated with BNP and NT‐proBNP levels in patients with heart failure
Author(s) -
Hogenhuis Jochem,
Voors Adriaan A.,
Jaarsma Tiny,
Hoes Arno W.,
Hillege Hans L.,
Kragten Johannes A.,
Veldhuisen Dirk J.
Publication year - 2007
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1016/j.ejheart.2007.04.001
Subject(s) - medicine , heart failure , natriuretic peptide , ejection fraction , cardiology , renal function
Background Anaemia may affect B‐type natriuretic peptide (BNP) and N‐terminal proBNP (NT‐proBNP) levels, but this has not been well described in heart failure (HF) patients without the exclusion of patients with renal dysfunction. Aims To study the influence of both anaemia and renal function on BNP and NT‐proBNP levels in a large group of hospitalised HF patients. Methods and results We studied 541 patients hospitalised for HF (mean age 71±11 years, 62% male, and left ventricular ejection fraction 0.33±0.14). Of these patients, 30% ( n =159) were anaemic (women: Hb <7.5 mmol/l, men: Hb <8.1 mmol/l). Of the 159 anaemic patients, 73% had renal dysfunction (eGFR<60 ml/min/1.73 m 2 ) and of the non‐anaemic patients, 57% had renal dysfunction. BNP and NT‐proBNP levels were measured in all patients before discharge. In multivariable analyses both plasma haemoglobin and eGFR were independently related to the levels of BNP and NT‐proBNP (standardised beta's of –0.16, –0.14 [BNP] and –0.19, –0.26 [NT‐proBNP] respectively, P ‐values<0.01). Conclusion Anaemia and renal dysfunction are related to increased BNP and NT‐proBNP levels, independent of the severity of HF. These results indicate that both anaemia and renal dysfunction should be taken into consideration during the interpretation of BNP and NT‐proBNP levels in HF patients.