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Response of the oxygen uptake efficiency slope to exercise training in patients with chronic heart failure
Author(s) -
Van Laethem Christophe,
Van De Veire Nico,
De Backer Guy,
Bihija Salhi,
Seghers Tony,
Cambier Dirk,
Vanderheyden Marc,
De Sutter Johan
Publication year - 2007
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1016/j.ejheart.2007.01.007
Subject(s) - medicine , cardiology , heart failure , anaerobic exercise , ejection fraction , watt , physical therapy , cardiopulmonary exercise test , vo2 max , heart rate , power (physics) , physics , quantum mechanics , blood pressure
Background: The oxygen uptake efficiency slope (OUES) is a new exercise parameter that provides prognostic power in patients with CHF. Little is known about the effects of exercise training (ET) on OUES. Aim: To describe the response of OUES to 6 months of ET in CHF patients and compare its evolution to that of other exercise variables. Methods: 35 patients with CHF (NYHA II–III, age 54±9y, LVEF 31±10%) performed 3 maximal exercise tests, i.e. at the start, middle and end of a 6 month ET program. OUES, PeakVO 2 , ventilatory anaerobic threshold (VAT) and slope VE/VCO 2 were determined. Results: OUES, peakVO 2 , VAT, slope VE/VCO 2 , peak Watt, 6MWT and NYHA‐class improved during the first part of the ET period ( p <0.05). Only VAT, peak Watt and 6MWT continued to improve during the second part of the ET period ( p >0.05) Improvements in OUES correlated better with improvements in peakVO 2 ( r =0.77, p <0.001), than changes in other prognostic variables. Discussion: OUES improves significantly after 6 months of ET. Changes in peakVO 2 correlate best with changes in OUES. OUES is sensitive to ET and can be used to evaluate the progression of exercise capacity in CHF patients.