Premium
Impact of diabetes on left ventricular diastolic function in patients with arterial hypertension
Author(s) -
Wachter Rolf,
Lüers Claus,
Kleta Sibylle,
Griebel Kerstin,
HerrmannLingen Christoph,
Binder Lutz,
Janicke Nico,
Wetzel Dirk,
Kochen Michael M.,
Pieske Burkert
Publication year - 2007
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1016/j.ejheart.2007.01.001
Subject(s) - medicine , cardiology , diabetes mellitus , diastole , blood pressure , body mass index , diastolic heart failure , coronary artery disease , logistic regression , cohort , endocrinology
Aims To analyse the effect of diabetes (DM) on diastolic function in hypertensive patients. Methods 439 hypertensive patients were selected for participation in this study. All participants had an echocardiographic evaluation of systolic and diastolic function. The overall degree of diastolic function and specific parameters (e.g. E/Ea ratio) were analysed. Results We divided the cohort (63±10 years) into those with diabetes mellitus (DM(+), n =124) and without diabetes mellitus (DM(–), n =315). The prevalence of normal diastolic function was lower in DM(+) than DM(–) (19.4% vs. 30.8%); mild (65.3% vs. 60.0%) and moderate/ severe diastolic dysfunction were more frequent in DM(+) (15.3% vs. 9.2%, p=0.022). The E/Ea ratio, an estimate of left ventricular end‐diastolic pressure, was significantly higher in DM(+) (12.3±4.4) as compared to DM(–) (10.8±3.6, p<0.001). Sex‐specific analysis revealed that the effect of DM on diastolic function was mainly limited to the male subgroup. Multivariate logistic regression analysis showed that diabetes affected diastolic function in males independent of blood pressure, left ventricular mass index, concomitant medication and prevalence of coronary artery disease. Conclusion Diabetes negatively affects diastolic function in patients with arterial hypertension. This effect is mainly confined to the male subgroup.