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Effects of aspirin and clopidogrel on plasma brain natriuretic peptide in patients with heart failure receiving ACE inhibitors
Author(s) -
Meune Christophe,
Wahbi Karim,
Fulla Yvonne,
CohenSolal Alain,
Duboc Denis,
Mahé Isabelle,
Simoneau Guy,
Bergmann JeanFrançois,
Weber Simon,
Mouly Stéphane
Publication year - 2007
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1016/j.ejheart.2006.06.003
Subject(s) - medicine , clopidogrel , heart failure , aspirin , brain natriuretic peptide , cardiology , natriuretic peptide
Background By inhibiting prostaglandins, aspirin may be deleterious in heart failure (HF) and/or may counteract angiotensin‐converting enzyme (ACE) inhibitor efficacy. Conversely, clopidogrel has no effect on prostaglandin metabolism. Aim To investigate the effect of aspirin and clopidogrel on brain natriuretic peptide (BNP) levels in HF patients treated with ACE inhibitors. Methods 36 patients with stable HF (65±13 years, 24 males/12 females, NYHA class II to IV, ejection fraction <40%, 13 with coronary disease, all treated with ACE inhibitors) were enrolled in this prospective, double‐blind study and randomised to aspirin 325 mg/day or clopidogrel 75 mg/day for 14 days. BNP was determined at day 0 and day 14. Results 19 patients were randomised to aspirin and 17 to clopidogrel. Baseline characteristics were similar in both groups. BNP levels increased in the aspirin group from day 0 to day 14 (107±103 to 144±149 pg/ml, p =0.04) whereas clopidogrel had no effect (104±107 and 97±99 pg/ml respectively, p =0.61). Conclusion This study demonstrates an adverse effect of aspirin 325 mg/day on BNP plasma levels in HF patients treated with ACE inhibitors. In contrast clopidogrel 75 mg/day had no effect.