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Viewpoint: The prothrombotic state in heart failure: A maladaptive inflammatory response?
Author(s) -
Chong AunYeong,
Lip Gregory Y.H.
Publication year - 2007
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1016/j.ejheart.2006.05.009
Subject(s) - medicine , heart failure , cardiology , thrombus , stroke (engine) , thrombosis , inflammation , venous thromboembolism , inflammatory response , mechanical engineering , engineering
Patients with heart failure (HF) are at an increased risk of stroke, sudden death and venous thromboembolism, which are all linked to thrombus formation (thrombogenesis). The present ‘viewpoint’ article will discuss how the prothrombotic state in HF may be perpetuated by a chronic inflammatory state that is maladaptive. Indeed, there is considerable evidence that thrombogenesis and endothelial (dys)function can be intimately linked to inflammation in HF.